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January, 2004

The Insanity of Mad Cow Madness
By Jim Scanlon

   One sick mad cow in Canada last May prompted the US, and other countries to immediately ban Canadian beef. Since May, the Canadian loss to agriculture has been estimated at $2.5 billion. Now, one sick "downer" cow in Yakima Washington testing positive for bovine spongiform encephalopathy (BSE), mad cow disease, provoked a similar, but much larger uproar. Within minutes of the announcement, country after country, as if  waiting anxiously to act, banned US beef imports, stock prices of meat packers and processors dropped, and urgent nervous, pathetic, appeals from governmental officials began to "reassure" the meat eating public that the US food supply was safe. President Bush issued an official statement urging Americans to continue, as he was-eating beef!
   What is so startling and awe inspiring is that the American people, mostly oblivious to the corporatization of their food supply and farming over the last few decades, and the resultant environmental destruction and threat to public health, is instantly horrified by the infinitesimally small and remote prospect that  "eating beef" that might have molecules of BSE, might result in crippling, spastic dementia and death. Day after day, page after newspaper page, endless reports on radio and television.
   A nation with a government in almost total denial regarding environmental pollution and climate change, resistant to the most minimal measures to slow down the degradation, aggressively and coercively resistant to attempts to regulate big business, restricting pesticides or hormones in the food supply, suddenly is horrified and paralyzed by global public hysteria and the godlike invisible punitive fist of the stock market
   Consider for just a minute what this is hysteria is all about.
   Over a twenty year period  approximately 145 people in the United Kingdom have died or been diagnosed with a new strain of Creutzfeldt Jacob  Disease (CJD) a rare but common, degenerative brain disease well known worldwide, with an incidence of 1 to 1.5 per million inhabitants. The new variant of CJD, usually referred to as vCJD or nvCJD, is basically confined to the United Kingdom, which, with a population of approximately 56 million, would be expected to have had a naturally occurring death rate of from 960 to 1,300 victims in twenty years.
   Diagnosis of both varieties is often difficult due to the small number of cases, confusion with Alzheimer's Disease and cases that may ignored and, or, masked as suicidal depression.
   In the UK, as of November 2002, the cumulative total was 129  cases of vCJD, listed as 93 confirmed, 24 probable and 12 strongly suspected-but not yet confirmed cases. In December 2003, the cumulative number of diagnosed  cases is variously given as 140, 143 and 147. Even considering a potentially long latency, with billions of exposures from "eating beef" over a twenty year period, 147 cases would suggest an extremely low rate of infection and-at the very least-greater specificity regarding what kind of "beef" eaten-or perhaps-some other manner of exposure to the infectious agent such as medicines, cosmetics, transplanted tissue (heart valves). made from slaughtered cattle.
   The difference between the closely related strains of vCJD and CJD  seems real, with slightly different effects on diseased brains and different age groups: the average age for vCJD is age 29, CJD is 60. But the time from the first appearance of symptoms until death is months, for both.
   In 1988, G. Carlton Gaydusek was awarded the Noble Prize for his work explaining Kuru, another transmissible spongiform encephalopathy very similar to vCJD which was epidemic among a certain tribe in New Guinea during the 1950s and 1960s. The disease disappeared without any scientific or medical intervention when Australian Colonial authorities banned a the religious funerary practice of the natives which involved in dismembering the entire bodies of honored relatives and eating them in a ritual communion meal. (Regulators take note!)
    This native practice is commonly referred to as cannibalism, which it is, but, Gaydusek did not stress the "eating," but the "preparation" which explained the greater incidence of the disease among women who in preparation of the dead body might expose a scratch to nerve tissue, or rub her eye. Children who were often present might do the same.
   Exposure through "preparation" and not "eating" would seem to be supported by confirmed transmission of disease though medical procedures. Transplantation of brain tissue (dura membrane), corneal transplants and contaminated brain probes  have been implicated
   Since neurosurgeons have been infected, one would think that farmers, meat packers and butchers would be vulnerable, but that is not the case.
   Between 1957 and 1980 approximately 2000 patients, mostly children, were injected with an extract of Human Growth Hormone made from pituitary glands taken from cadavers. The treatment was effective in promoting growth, but unfortunately the treatment promoted infectious CJD particles. The exact number who died is not known, but believed to be greater than 147. Some 220 court cases were filed for negligence. (The production of Human Growth Hormone with Cadaver tissue was abandoned in 1985.
   Here is how Nature, (25 April 1996) the International Journal of Science described the process:
   "Over the period when hGH was extracted from cadavers, nearly one million pituitary glands were used in the United Kingdom. Mortuary attendants removed the glands and at one stage "received a nominal fee of twenty pence per gland". This system was later changed and mortuary attendants were paid a flat rate for the extra work involved in removing the glands."
   It is something of a mystery how neurosurgeons could be infected, but mortuary assistants sawing and hacking open a million skulls were not. Also strange and unexplained is how a "Prion" protein could survive a voyage through the gut and  pass the blood brain barrier.
   The scientific literature contains another strange case of an epidemic of a similar neurological disease on the Pacific Island of Guam attributed to the consumption of the fruit of the false sego palm during the Japanese occupation during World War II.
   Since the 1700s sheep have been known to suffer from  a degenerative brain disease called scrapie. Although transmission to other species including man was not known, it was suspected. Infection could be induced only by direct inoculation of infected brain tissue directly into a healthy brain.
   It is commonly believed that the practice of processing dead sheep into protein supplements for cattle led to the development of BSE. The use of processed animal carcasses in cattle feed was banned in the UK in 1988 and in the US in 1996.
   The BSE epidemic peaked 1992 when 138,000 cases were diagnosed. Overall some 3,500,000 cattle were slaughtered-an enormous waste! In 2002 the number of cases was down to 755 in the UK and 291 elsewhere. Over all those years with all those infected cattle and all those roast beef sandwiches there were apparently 147 diagnosed cases of vCJD-horrible tragedies for the victims and their families, but hardly a public health threat.
   Although most bans on its beef have now been lifted, the cost to agriculture and society in the UK cannot really be imagined. Neither can the effect the disaster has had strengthening regional nationalism and weakening the European Union.
   Although the US  has banned the use of recycled cow carcasses in cattle feed, it is allowable in chicken and pig feed. Paradoxically chicken and pork are recommended to replace beef. The recent spate of articles on the food chain has revealed a few of the odd practices of the factory farming. Cattle blood is processed as a feed supplement for calves, thus seeming to evade the cattle to cattle food chain. And when chickens are fed feed with ground cattle protein, the residue, when swept up swept up from the floor, presumably with chicken excrement, can be fed to cattle.
   One of the big winners in this affair would appear to be Dr. Stanley Pruisner of UCSF who won the Noble Prize for his work on "prions" the putative infectious agent in transmissible encephalopathy. There was great resistance among many scientists to the idea that an infectious protein molecule, without DNA or RNA could adapt or evolve into different strains and Pruisner was viciously attacked in the New Yorker magazine of all places.
   Dr. Pruisner, who rigorously avoided contact with the media (in the late 1980s he never returned, or taken, telephone calls from the Coastal Post) was featured on the front page of the New York Times before Christmas. He seems to have lost his shyness now that he has developed a diagnostic test for BSE, which could net him and UCSF a fortune in royalties The next day the stock price of the company that markets the r test jumped.
   The US Dept. of Agriculture tested 20,526 of the 35,000,000 cattle slaughtered last year. Any increase in the number of tests obviously seems to be a good for business, and, after all, that's what counts today.
   Genetically modified tofu anyone?

 

 

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